Proteomics Group, Institute of Functional Genomics, University Regensburg 










    Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling     in Hepatocellular Carcinoma.

    Engelmann JC, Amann T, Ott-Rötzer B, Nützel M, Reinders Y, Reinders J, Thasler WE, Kristl T, Teufel A, Huber CG, Oefner PJ,         Spang R, Hellerbrand C.
    PLoS Comput Biol. 2015 May 28;11(5)
    Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues.
    Wolfertstetter S, Reinders J, Schwede F, Ruth P, Schinner E, Schlossmann J.
    PLoS One. 2015 May 15;10(5)

    Selenophosphate synthetase in the male accessory glands of an insect without selenoproteins.
    Fuessl M, Reinders J, Oefner PJ, Heinze J, Schrempf A.
     J Insect Physiol. 2014 Dec;71:46-51.
    A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood     samples.
    Pauly D, Nagel BM, Reinders J, Killian T, Wulf M, Ackermann S, Ehrenstein B, Zipfel PF, Skerka C, Weber BH.
    PLoS One. 2014 May 5;9(5)
    Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell     carcinoma.
    Bedal KB, Grässel S, Oefner PJ, Reinders J, Reichert TE, Bauer R.
    PLoS One. 2014 Jan 23;9(1)
    Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome.
    Klootwijk ED, Reichold M, Helip-Wooley A, Tolaymat A, Broeker C, Robinette SL, Reinders J, Peindl D, Renner K, Eberhart K,             Assmann N, Oefner PJ, Dettmer K, Sterner C, Schroeder J, Zorger N, Witzgall R, Reinhold SW, Stanescu HC, Bockenhauer D,             Jaureguiberry G, Courtneidge H, Hall AM, Wijeyesekera AD, Holmes E, Nicholson JK, O'Brien K, Bernardini I, Krasnewich DM,             Arcos-Burgos M, Izumi Y, Nonoguchi H, Jia Y, Reddy JK, Ilyas M, Unwin RJ, Gahl WA, Warth R, Kleta R.
    N Engl J Med. 2014 Jan 9;370(2):129-38.
    N-cadherin promoter polymorphisms and risk of osteoarthritis.
    Ruedel A, Stark K, Kaufmann S, Bauer R, Reinders J, Rovensky J, Blazicková S, Oefner PJ, Bosserhoff AK.
    FASEB J. 2014 Feb;28(2):683-91.
    Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines.
    Bauer K, Gosau M, Reinders J, Oefner P, Reichert TE, Bauer R.
    Carcinogenesis. 2013 Nov;34(11):2622-8.
    Thomas A, Klein MS, Stevens AP, Reinders Y, Hellerbrand C, Dettmer K, Gronwald W, Oefner PJ, Reinders J (2013)
    Changes in the hepatic mitochondrial and membrane proteome in mice fed a non-alcoholic steatohepatitis inducing diet.

    J Proteomics. 2013 Jan 9;80C:107-122.

    Demir F, Horntrich C, Blachutzik JO, Scherzer S, Reinders Y, Kierszniowska S, Schulze WX, Harms GS, Hedrich R, Geiger D,             Kreuzer I (2013)
    Arabidopsis nanodomain-delimited ABA signaling pathway regulates the anion channel SLAH3.

    Proc Natl Acad Sci U S A. 2013 Apr 29.

    Pietzner J, Baer PC, Duecker RP, Merscher MB, Satzger-Prodinger C, Bechmann I, Wietelmann A, Del Turco D, Doering C, Kuci S,
    Bader P, Schirmer S, Zielen S, Schubert R (2013)
    Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells.
    Hum Mol Genet. 2013 Feb 1;22(3):493-507.

   Escalante-Pérez M, Jaborsky M, Reinders J, Kurzai O, Hedrich R, Ache P (2012)
     Poplar Extrafloral Nectar Is Protected against Plant and Human Pathogenic Fungus.
     Mol Plant. 2012 Aug;5(5):1157-59.

     Thomas A, Stevens AP, Klein MS, Hellerbrand C, Dettmer K, Gronwald W, Oefner PJ, Reinders J (2012)
     Early changes in the liver-soluble proteome of mice fed a nonalcoholic steatohepatits inducing diet.
Proteomics. 2012 May;12(9):1437-51.

     Sanges C, Scheuermann C, Zahedi RP, Sickmann A, Lamberti A, Miggliaccio N, Baljlus A, Marra M, Zappavigna S, Reinders J,          Rapp U, Abbruzzese A, Caraglia M, Arcari P (2012)
     Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells.
 Cell Death Dis. 2012 Mar;1(3):e276. Erratum in: Cell Death Dis. 2012;3:e317.   

Wingenter K, Trentmann O, Winschuh I, Hörmiller II, Heyer AG, Reinders J, Schulz A, Geiger D, Hedrich R, Neuhaus HE (2011)
     A member of the mitogen-activated protein 3-kinase family is involved in the regulation of plant vacuolar glucose uptake.
 Plant J. 2011 Dec;68(5):890-900.

Voss K, Stahl S, Hogan BM, Reinders J, Schleider E, Schulte-Merker S, Felbor U (2009)
     Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral              cavernous malformation 3 protein.
Hum Mutat. 2009 Jun;30(6):1003-11.

    Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR. (2009)
    Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of             14-3-3 proteins. J Biol Chem. 284(5):3183-94.
    Filatova A, Leyerer M, Gorboulev V, Chintalapati C, Reinders Y, Müller TD, Srinivasan A, Hübner S, Koepsell H (2009)

    Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location.
    Traffic. 2009 Nov;10(11):1599-618


    Randolt, K., Gimple, O., Geißendörfer, J., Reinders, J., Prusko, C., Mueller, M.J., Albert, S., Tautz, J., Beier, H.
    Immune-related proteins induced in the hemolymph after aseptic and septic injury differs in honey bee worker larvae and adults.
Arch. Insect. Biochem. Physiol.

    Dueckershoff, K., Mueller, S., Mueller, M.J., Reinders, J.
    Impact of cyclopentenone-oxylipins on the proteome of
Arabidopsis thaliana.
    Biochim. Biophys. Acta

    Hennig A., Reinders Y., Giritch A., Reinders J. and Warzecha H.
    Assessment of different expression strategies for the production of a recombinant lipoprotein vaccine in plants.
    The Open Biotechnology Journal. 2008. 2:51-5.


    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., Van der Laan M., Rehling P., Sickmann A., Pfanner N. and
    Meisinger C.

    Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.
    Mol Cell Proteomics. 2007. 6:1896-906.

    Schönleben S., Sickmann A., Mueller M.J. and Reinders J.
    Proteome analysis of Apis mellifera royal jelly
    Anal Bioanal Chem. 2007. 389:1087-94.

    Stahl S., Reinders Y., Asan E., Mothes W., Conzelmann E., Sickmann A. and Felbor U.
    Proteomic analysis of cathepsin B and L-deficient mouse brain lysosomes.
    Biochim Biophys Acta. 2007. 1774:1237-46.

    Reinders J. and Sickmann A.
     Proteomics of Yeast Mitochondria. In: Mitochondria Practical Protocols.

    Methods Mol Biol. 2007. 372:543-57.

    Reinders J. and Sickmann A.
     Modificomics: Posttranslational modifications beyond protein phosphorylation and glycosylation.

    Biomol Eng. 2007. 24(2):169-77.


    Koch K.V., Reinders Y., Ho T.H., Sickmann A. and Gräf R.

    Identification and isolation of Dictyostelium microtubule-associated protein interactors by tandem affinity purification.
    Eur J Cell Biol. 2006. Sep; 85(9-10):1079-90.

    Reinders J., Zahedi R.P., Pfanner N., Meisinger C. and Sickmann A.
    Toward the Complete Yeast Mitochondrial Proteome: Multidimensional Separation Techniques for Mitochondrial  

    J Proteome Res. 2006 Jul; 5(7):1543-54.

    Hahlen K., Ebbing B., Reinders J., Mergler J., Sickmann A. and Woehlke G.
    Feedback of Kinesin-1's Neck-Linker Position on the Catalytic Site.
    J Biol Chem. 2006 Jul; 281(27):18868-77.

    Reinders J., Meyer H.E. and Sickmann A.
    Applications of highly sensitive phosphopeptide derivatization methods without the need for organic solvents.
    Proteomics. 2006 Apr;6(9):2647-49.

    Reinders Y., Schulz I., Gräf R. and Sickmann A.
    Identification of novel centrosomal proteins in D. discoideum by comparative proteomic approaches.
    J Proteome Res. 2006 Mar;5(3):589-98.

    Schulz I., Reinders Y., Sickmann A. and Gräf R.
    An improved method for Dictyostelium centrosome isolation.
    In: Dictyostelium discoideum protocols, Methods Mol Biol. 2006; Vol. 346:479-90, Humana Press.


    Reinders J. and Sickmann A.

    State-of-the-art in phosphoproteomics.
    Proteomics. 2005 Nov;5(16):4052-61.

    Putz S., Reinders J., Reinders Y. and Sickmann A.
    Mass spectrometry-based peptide quantification: applications and limitations.
    Expert Rev Proteomics. 2005 Jun;2(3):381-92.


    Reinders J., Lewandrowski U., Moebius J., Wagner Y. and Sickmann A.

    Challenges in mass spectrometry-based proteomics.
    Proteomics. 2004 Dec;4(12):3686-703.


    Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R., Meyer H.E., Schonfisch B., Perschil I., Chacinska A., Guiard
    B., Rehling P., Pfanner N. and Meisinger C.

    The proteome of Saccharomyces cerevisiae mitochondria.
    Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13207-12.

    Wagner, Y., Sickmann, A., Meyer, H.E. and Daum, G.
    Multidimensional nano-HPLC for analysis of protein complexes.
    J Am Soc Mass Spectrom. 2003 Sep;14(9):1003-11.

    Wagner, Y., Sickmann, A. and Meyer, H.E.
    Multidimensionale nano-HPLC-MS/MS zur Analyse von Proteinkomplexen und Proteingemischen.
    Biospektrum2002; 492-495.